In Drosophila, the circadian clock regulates daily rhythms in transcription via rhythmic binding of CLK and RNA Polymerase (Pol) II to the promoters of clock genes including Per, Doubletime (Dbt; Ck1 in mammals) and Shaggy (Sgg, Gsk3b in mammals) [36, 105]. The kinase SGG regulates nuclear accumulation of the PER/TIM repressor complex [95, 106, 107], whereas DBT regulates its stability [108,109,110]. In addition to DBT, several other kinases (e.g., NEMO, CK2, and PKA) [108, 111,112,113] and a few phosphatases (e.g., PP1 and PP2a) [114, 115] have been identified as regulators of PER and PER/TIM stability in Drosophila. In the fruit fly Drosophila, the expression of Per and several other clock and clock-controlled genes peak during the night-time . Similar to Drosophila, we observed a night-time peak in Per expression for C. floridanus foragers, which is also consistent with previous findings in fire ants and honeybees [14, 104]. Additionally, the phase of diurnal Per expression in C. floridanus foragers is consistent with the phase of oscillating PER abundance previously reported for the species . For instance, the expression of Per and its protein product, both, peak at lights on (ZT24/ZT0). This is followed by a sharp decrease of Per at ZT2 which could explain, in part, the gradual decline in PER abundance during the day-time that has been reported by Kay and colleagues .
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The damage done by agriculture is social and political as well. A surplus, rare and ephemeral for foragers, is a principal goal of agriculture. A surplus must be stored, which requires technology and materials to build storage, people to guard it, and a hierarchical organization to centralize the storage and decide how it will be distributed. It also offers a target for local power struggles and theft by neighboring groups, increasing the scale of wars. With agriculture, power thus begins its concentration into fewer and fewer hands. He who controls the surplus controls the group. Personal freedom erodes naturally under agriculture. 59ce067264